Polylactic acid/multi walled carbon nanotubes (PLA/MWCNT) nanocomposite for 3D printing of medical devices
DOI:
https://doi.org/10.37636/recit.v44388398Keywords:
Polylactic acid (PLA), Multi walled carbon nanotubes (MWCNT), 3D printing, Biomaterials, NanocompositesAbstract
In recent years, the composite nanomaterials area has had a great development impact in health sciences. Biomaterials depict as one of the most promising since they are compatible with additive manufacturing (AM) techniques. It is also possible to use them to mold specific medical parts. Composite nanomaterials have shown good biocompatibility and low toxicity to have benefits equal to or greater than metals (i.e., Co-Cr alloy). The purpose of this study is to develop a nanocomposite biomaterial (PLA/MWCNTf) from Polylactic Acid (PLA) and functionalized Multi Walled Carbon Nanotubes (MWCNTf) to evidence its potential application in 3D printing of orthopedic fixation devices. PLA/MWCNTf nanocomposite was prepared by solution blending technique, incorporating a proportion of 0.5 wt% of MWCNTf to the PLA matrix. TGA analysis of the PLA/MWCNTf was used to determine the thermal stability, a slight increase was found compared to the PLA. FTIR spectroscopy confirmed the presence of carboxylic acid groups in the MWCNTf which improves good incorporation of the nanotubes in the PLA matrix. Additionally, Raman spectroscopy, SEM, and AFM micrographs were used to verify MWCNTf reached the PLA surface homogeneously. Additive manufacturing preparation was done by extrusion molding of PLA/MWCNTf as well as its 3D printing.
Downloads
References
L. M. Ricles, J. C. Coburn, M. Di Prima, and S. S. Oh, "Regulating 3D-printed medical products," Sci. Transl. Med., vol. 10, no. 461, pp. 1-7, 2018. https://doi.org/10.1126/scitranslmed.aan6521. DOI: https://doi.org/10.1126/scitranslmed.aan6521
M. Di Prima, J. Coburn, D. Hwang, J. Kelly, A. Khairuzzaman, and L. Ricles, "Additively manufactured medical products - the FDA perspective," 3D Print. Med., vol. 2, no. 1, pp. 4-9, 2016. https://doi.org/10.1186/s41205-016-0005-9. DOI: https://doi.org/10.1186/s41205-016-0005-9
Norma Oficial Mexicana, NOM-240-SSA1-2011, Instalación y operación de la tecnovigilancia. 2012, p. 13. http://www.dof.gob.mx/normasOficiales/4600/salud/salud.htm
J. J. Devlin, A. C. Pomerleau, J. Brent, B. W. Morgan, S. Deitchman, and M. Schwartz, "Clinical Features, Testing, and Management of Patients with Suspected Prosthetic Hip-Associated Cobalt Toxicity: A Systematic Review of Cases," J. Med. Toxicol., vol. 9, no. 4, pp. 405-415, 2013. https://doi.org/10.1007/s13181-013-0320-0 DOI: https://doi.org/10.1007/s13181-013-0320-0
J. R. Campbell and M. P. Estey, "Metal release from hip prostheses: Cobalt and chromium toxicity and the role of the clinical laboratory," Clin. Chem. Lab. Med., vol. 51, no. 1, pp. 213-220, 2013. https://doi.org/10.1515/cclm-2012-0492. DOI: https://doi.org/10.1515/cclm-2012-0492
B. Green, E. Griffiths, and S. Almond, "Neuropsychiatric symptoms following metal-on-metal implant failure with cobalt and chromium toxicity," BMC Psychiatry, vol. 17, no. 1, pp. 1-5, 2017. https://doi.org/10.1186/s12888-016-1174-1. DOI: https://doi.org/10.1186/s12888-016-1174-1
L. Leyssens, B. Vinck, C. Van Der Straeten, F. Wuyts, and L. Maes, "Cobalt toxicity in humans-A review of the potential sources and systemic health effects," Toxicology, vol. 387, pp. 43-56, 2017. https://doi.org/10.1016/j.tox.2017.05.015. DOI: https://doi.org/10.1016/j.tox.2017.05.015
A. C. Cheung et al., "Systemic cobalt toxicity from total hip arthroplasties," Bone Jt. J., vol. 98B, no. 1, pp. 6-13, 2016. https://doi.org/10.1302/0301-620X.98B1.36374 DOI: https://doi.org/10.1302/0301-620X.98B1.36374
A. Vaicelyte, C. Janssen, M. Le Borgne, and B. Grosgogeat, "Cobalt-Chromium Dental Alloys: Metal Exposures, Toxicological Risks, CMR Classification, and EU Regulatory Framework," Crystals, vol. 10, no. 12, p. 1151, 2020. https://doi.org/10.3390/cryst10121151. DOI: https://doi.org/10.3390/cryst10121151
T. Ikeda, K. Takahashi, T. Kabata, D. Sakagoshi, K. Tomita, and M. Yamada, "Polyneuropathy caused by cobalt-chromium metallosis after total hip replacement," Muscle and Nerve, vol. 42, no. 1, pp. 140-143, 2010. https://doi.org/10.1002/mus.21638. DOI: https://doi.org/10.1002/mus.21638
A. W. Schaffer, A. Pilger, C. Engelhardt, K. Zweymueller, and H. W. Ruediger, "Increased blood cobalt and chromium after total hip replacement," J. Toxicol. - Clin. Toxicol., vol. 37, no. 7, pp. 839-844, 1999. https://doi.org/10.1081/CLT-100102463. DOI: https://doi.org/10.1081/CLT-100102463
W. Apel, D. Stark, A. Stark, S. O'Hagan, and J. Ling, "Cobalt-chromium toxic retinopathy case study," Doc. Ophthalmol., vol. 126, no. 1, pp. 69-78, 2013. https://doi.org/10.1007/s10633-012-9356-8. DOI: https://doi.org/10.1007/s10633-012-9356-8
B. Scharf et al., "Molecular analysis of chromium and cobalt-related toxicity," Sci. Rep., vol. 4, no. 1, p. 5729, 2014. https://doi.org/10.1038/srep05729. DOI: https://doi.org/10.1038/srep05729
Q. Chen, J. D. Mangadlao, J. Wallat, A. De Leon, J. K. Pokorski, and R. C. Advincula, "3D printing biocompatible polyurethane/poly(lactic acid)/graphene oxide nanocomposites: Anisotropic properties," ACS Appl. Mater. Interfaces, vol. 9, no. 4, pp. 4015-4023, 2017. https://doi.org/10.1021/acsami.6b11793. DOI: https://doi.org/10.1021/acsami.6b11793
S. Liu et al., "Degradation behavior in vitro of carbon nanotubes (CNTs)/poly (lactic acid) (PLA) composite suture," Polymers (Basel)., vol. 11, no. 6, 2019. https://doi.org/10.3390/polym11061015. DOI: https://doi.org/10.3390/polym11061015
M. Gong, Q. Zhao, L. Dai, Y. Li, and T. Jiang, "Fabrication of polylactic acid/hydroxyapatite/graphene oxide composite and their thermal stability, hydrophobic and mechanical properties," J. Asian Ceram. Soc., vol. 5, no. 2, pp. 160-168, 2017. https://doi.org/10.1016/j.jascer.2017.04.001. DOI: https://doi.org/10.1016/j.jascer.2017.04.001
P. O. Andrade, M. A. V. M. Grinet, M. M. Costa, A. M. E. Santo, F. R. Marciano, and A. O. Lobo, "Poly (Lactic Acid) Fine Fibers Containing a Low Content of Superhydrophilic Multi-Walled Carbon Nanotube Graphene Oxide Hybrid as Scaffolds for Biological Applications," Macromol. Mater. Eng., vol. 303, no. 11, pp. 1-11, 2018. https://doi.org/10.1002/mame.201800317. DOI: https://doi.org/10.1002/mame.201800317
F. Alam, V. R. Shukla, K. M. Varadarajan, and S. Kumar, "Microarchitected 3D printed polylactic acid (PLA) nanocomposite scaffolds for biomedical applications," J. Mech. Behav. Biomed. Mater., vol. 103, p. 103576, 2020. https://doi.org/10.1016/j.jmbbm.2019.103576 DOI: https://doi.org/10.1016/j.jmbbm.2019.103576
C. H. Tsou et al., "Antibacterial property and cytotoxicity of a poly (lactic acid)/nanosilver-doped multiwall carbon nanotube nanocomposite," Polymers (Basel)., vol. 9, no. 3, 2017. https://doi.org/10.3390/polym9030100. DOI: https://doi.org/10.3390/polym9030100
A. F. Ahmad et al., "Biodegradable poly (lactic acid)/poly (ethylene glycol) reinforced multi-walled carbon nanotube nanocomposite fabrication, characterization, properties, and applications," Polymers (Basel)., vol. 12, no. 2, pp. 1-22, 2020. https://doi.org/10.3390/polym12020427. DOI: https://doi.org/10.3390/polym12020427
G. Spinelli et al., "Effects of filament extrusion, 3D printing and hot-pressing on electrical and tensile properties of poly (Lactic) acid composites filled with carbon nanotubes and graphene," Nanomaterials, vol. 10, no. 1, 2020. https://doi.org/10.3390/nano10010035. DOI: https://doi.org/10.3390/nano10010035
L. Yang et al., "Effects of carbon nanotube on the thermal, mechanical, and electrical properties of PLA/CNT printed parts in the FDM process," Synth. Met., vol. 253, no. December 2018, pp. 122-130, 2019. https://doi.org/10.1016/j.synthmet.2019.05.008. DOI: https://doi.org/10.1016/j.synthmet.2019.05.008
S. Azizi, M. Azizi, and M. Sabetzadeh, "The role of multiwalled carbon nanotubes in the mechanical, thermal, rheological, and electrical properties of PP/PLA/MWCNTS nanocomposites," J. Compos. Sci., vol. 3, no. 3, pp. 1-15, 2019. https://doi.org/10.3390/jcs3030064. DOI: https://doi.org/10.3390/jcs3030064
G. Spinelli et al., "Morphological, rheological and electromagnetic properties of nanocarbon/poly(lactic) acid for 3D printing: Solution blending vs. melt mixing," Materials (Basel)., vol. 11, no. 11, 2018. https://doi.org/10.3390/ma11112256. DOI: https://doi.org/10.3390/ma11112256
M. Kaseem, K. Hamad, F. Deri, and Y. G. Ko, "A review on recent researches on polylactic acid/carbon nanotube composites," Polym. Bull., vol. 74, no. 7, pp. 2921-2937, 2017. https://doi.org/10.1007/s00289-016-1861-6. DOI: https://doi.org/10.1007/s00289-016-1861-6
Y. Shen et al., "Chemical and thermal reduction of graphene oxide and its electrically-conductive polylactic acid nanocomposites," Compos. Sci. Technol., vol. 72, no. 12, pp. 1430-1435, 2012. https://doi.org/10.1016/j.compscitech.2012.05.018. DOI: https://doi.org/10.1016/j.compscitech.2012.05.018
C. Hu et al., "Comparative assessment of the strain-sensing behaviors of polylactic acid nanocomposites: reduced graphene oxide or carbon nanotubes," J. Mater. Chem. C, vol. 5, no. 9, pp. 2318-2328, 2017. https://doi.org/10.1039/C6TC05261D. DOI: https://doi.org/10.1039/C6TC05261D
C. Liu, J. Shen, K. W. K. Yeung, and S. C. Tjong, "Development and Antibacterial Performance of Novel Polylactic Acid-Graphene Oxide-Silver Nanoparticle Hybrid Nanocomposite Mats Prepared by Electrospinning," ACS Biomater. Sci. Eng., vol. 3, no. 3, pp. 471-486, 2017. https://doi.org/10.1021/acsbiomaterials.6b00766. DOI: https://doi.org/10.1021/acsbiomaterials.6b00766
A. M. Pinto, J. Cabral, D. A. P. Tanaka, A. M. Mendes, and F. D. Magalhães, "Effect of incorporation of graphene oxide and graphene nanoplatelets on mechanical and gas permeability properties of poly (lactic acid) films," Polym. Int., vol. 62, no. 1, pp. 33-40, 2013. https://doi.org/10.1002/pi.4290. DOI: https://doi.org/10.1002/pi.4290
B. W. Chieng, N. A. Ibrahim, W. M. Z. W. Yunus, M. Z. Hussein, Y. Y. Then, and Y. Y. Loo, "Effects of graphene nanoplatelets and reduced graphene oxide on poly (lactic acid) and plasticized poly (lactic acid): A comparative study," Polymers (Basel)., vol. 6, no. 8, pp. 2232-2246, 2014. https://doi.org/10.3390/polym6082232. DOI: https://doi.org/10.3390/polym6082232
K. Tappa et al., "3D printing custom bioactive and absorbable surgical screws, pins, and bone plates for localized drug delivery," J. Funct. Biomater., vol. 10, no. 2, 2019. https://doi.org/10.3390/jfb10020017. DOI: https://doi.org/10.3390/jfb10020017
A. Aguilar-Elguézabal, W. Antúnez, G. Alonso, F. P. Delgado, F. Espinosa, and M. Miki-Yoshida, "Study of carbon nanotubes synthesis by spray pyrolysis and model of growth," Diam. Relat. Mater., vol. 15, no. 9, pp. 1329-1335, 2006. https://doi.org/10.1016/j.diamond.2005.10.011. DOI: https://doi.org/10.1016/j.diamond.2005.10.011
L. S. Tejeda Aguayo, "Síntesis de nanotubos de carbono de pared múltiple (MWCNT) funcionalizados con el ácido 2,3-dihidroxibenzoico selectivo al Fe3+ como tratamiento potencial de talasemia", tesis de maestría, CGIQ., Instituto Tecnológico de Tijuana, Tijuana, México, 2018.
A. V. Rane, K. Kanny, V. K. Abitha, and S. Thomas, "Methods for Synthesis of Nanoparticles and Fabrication of Nanocomposites," in Synthesis of Inorganic Nanomaterials, Elsevier Ltd., 2018, pp. 121-139. https://doi.org/10.1016/B978-0-08-101975-7.00005-1. DOI: https://doi.org/10.1016/B978-0-08-101975-7.00005-1
J. H. Lehman, M. Terrones, E. Mansfield, K. E. Hurst, and V. Meunier, "Evaluating the characteristics of multiwall carbon nanotubes," Carbon N. Y., vol. 49, no. 8, pp. 2581-2602, 2011. https://doi.org/10.1016/j.carbon.2011.03.028. DOI: https://doi.org/10.1016/j.carbon.2011.03.028
Published
How to Cite
License
Copyright (c) 2021 Manuel Alejandro Cardona Salcedo, Mercedes Teresita Oropeza Guzmán, Grecia Isis Moreno Grijalva, Arturo Zizumbo López, Juan Antonio Paz González, Yadira Gochi Ponce
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors who publish in this journal accept the following conditions:
The authors retain the copyright and assign to the journal the right of the first publication, with the work registered with the Creative Commons Attribution license 4.0, which allows third parties to use what is published as long as they mention the authorship of the work and the first publication in this magazine.
Authors may make other independent and additional contractual agreements for the non-exclusive distribution of the version of the article published in this journal (eg, include it in an institutional repository or publish it in a book) as long as they clearly indicate that the work it was first published in this magazine.
Authors are allowed and encouraged to share their work online (for example: in institutional repositories or personal web pages) before and during the manuscript submission process, as it can lead to productive exchanges, greater and more quick citation of published work (see The Effect of Open Access).