Chitosan mucoadhesive films as controlled release system of nystatin for buccal application
DOI:
https://doi.org/10.37636/recit.v41118Keywords:
Chitosan, Polygalacturonic acid, Polyelectrolytes, Mucoadhesive, Films, Nystatin, Oropharyngeal Candidiasis, Sustained releaseAbstract
Oropharyngeal candidiasis is the most prevalent fungal disease in the world. The formulations of the drug of choice for its treatment have a low residence time and bioavailability at the site of infection. The aim of this study was to prepare and characterize mucoadhesive films of chitosan and polygalacturonic acid by the “Solvent-Casting” technique loaded with nystatin as a sustained release system for the oral cavity. The films obtained were characterized to determine their morphological characteristics, adhesion capacity, and degree of swelling and release profile of the drug. The morphology of the films was determined by scanning electron microscopy, the interaction between the polymers was determined by infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry, additionally, its antimicrobial activity against two Candida species was tested. The obtained films showed mucoadhesion capacity and a sustained release of the drug explained by the Korsemeyer-Peppas model, also a significant antimicrobial activity was found. These findings suggest that chitosan-based films are a possible nystatin release system for the oral cavity.
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Copyright (c) 2021 Efrain Armenta Rojas, Jose Manuel Cornejo Bravo, Aracely Serrano Medina , Eduardo Alberto López Maldonado , Amelia Olivas Sarabia, Nydia Alejandra Castillo Martínez, Ayla Carolina Vea Barragán
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