Chitosan mucoadhesive films as controlled release system of nystatin for buccal application


  • Efraín Armenta Rojas Facultad de Ciencias Químicas e Ingeniería
  • José Manuel Cornejo Bravo Facultad de Ciencias Químicas e Ingeniería
  • Aracely Serrano Medina Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Baja California, México
  • Eduardo Alberto López Maldonado Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Unidad Otay, Tijuana, Baja California, México
  • Amelia Olivas Sarabia Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Ensenada, Baja California, México
  • Nydia Alejandra Castillo Martínez Facultad de Ciencias de la Salud, Universidad Autónoma de Baja California, Unidad Valle de las Palmas, Tijuana, Baja California, México
  • Ayla Carolina Vea Barragán Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Unidad Otay, Tijuana, Baja California, México



Chitosan, Polygalacturonic acid, Polyelectrolytes, Mucoadhesive, Films, Nystatin, Oropharyngeal Candidiasis, Sustained release


Oropharyngeal candidiasis is the most prevalent fungal disease in the world. The formulations of the drug of choice for its treatment have a low residence time and bioavailability at the site of infection. The aim of this study was to prepare and characterize mucoadhesive films of chitosan and polygalacturonic acid by the “Solvent-Casting” technique loaded with nystatin as a sustained release system for the oral cavity. The films obtained were characterized to determine their morphological characteristics, adhesion capacity, and degree of swelling and release profile of the drug. The morphology of the films was determined by scanning electron microscopy, the interaction between the polymers was determined by infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry, additionally, its antimicrobial activity against two Candida species was tested. The obtained films showed mucoadhesion capacity and a sustained release of the drug explained by the Korsemeyer-Peppas model, also a significant antimicrobial activity was found. These findings suggest that chitosan-based films are a possible nystatin release system for the oral cavity.


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Electron micrographs of CPE films. to. QUI-APG Placebo film surface b. QUI-APG film surface loaded with NIS. c. QUI-APG Placebo film cross section d. Cross section of QUI-APG film loaded with NIS. Arrows indicate precipitated drug crystals.



How to Cite

Armenta Rojas, E., Cornejo Bravo, J. M., Serrano Medina , A., López Maldonado , E. A., Olivas Sarabia, A., Castillo Martínez, N. A., & Vea Barragán, A. C. (2021). Chitosan mucoadhesive films as controlled release system of nystatin for buccal application. REVISTA DE CIENCIAS TECNOLÓGICAS, 4(1), 1–18.



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