Toxicity evaluation of thermosensitive nanogels in an in vivo model

Authors

  • Alondra Montañez Rios Universidad Autónoma de Baja California, Facultad de Ciencias Químicas e Ingeniería, Calzada Universidad 14418, Parque industrial Internacional, Tijuana, Baja California, México, C.P. 22427. https://orcid.org/0000-0001-6784-9605
  • Aracely Serrano Medina Universidad Autónoma de Baja California, Facultad de Medicina y Psicología, Calzada Universidad 14418, Parque industrial Internacional, Tijuana, Baja California, México, C.P. 22427.
  • Juan M. Irache NANO-VAC Research Group, Department of Chemistry and Pharmaceutical Technology, University of Navarra, Pamplona 31080, Spain. https://orcid.org/0000-0001-9687-3436
  • Ana Luisa Martínez López NANO-VAC Research Group, Department of Chemistry and Pharmaceutical Technology, University of Navarra, Pamplona 31080, Spain.
  • Ignacio Alfredo Rivero Espejel Tecnológico Nacional de México/I. T. Tijuana. Centro de Graduados e Investigación en Química, Blvd. Alberto Limón Padilla S/N, 22510 Tijuana, Baja California, México https://orcid.org/0000-0003-4920-6379
  • Jose Manuel Cornejo Bravo Universidad Autónoma de Baja California, Facultad de Ciencias Químicas e Ingeniería, Calzada Universidad 14418, Parque industrial Internacional, Tijuana, Baja California, México, C.P. 22427. https://orcid.org/0000-0002-0013-8937

DOI:

https://doi.org/10.37636/recit.v5n3e236

Keywords:

Nanogels, C. elegans, NIPAAm, Toxicity

Abstract

This study uses C. elegans to assess the toxicity of copolymeric nanogels (NG) of N-isopropylacrylamide (NIPAAm) and 2-(diethylamino)ethyl methacrylate (DEAEM), prepared by surfactant-free emulsion polymerization using polyethylene glycol monomethyl ether methacrylate (PEGMA) as a reactive stabilizer. Nematodes ingested fluorescein-labeled NG, as demonstrated by fluorescence microscopy. Two different initiators, cationic and anionic, were used to initiate the synthesis of the NG. The results indicate that both types of NG affect the size and reproducibility of nematodes. C. elegans is a potential multicellular model to evaluate the toxicity of sensitive NG, avoiding the use of mammals for evaluations.

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References

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Field emission scanning electron microscope (FESEM) images of AIBA-initiated nanogels

Published

2022-10-09

How to Cite

Montañez Rios, A., Serrano Medina , A., Irache , J. M., Martínez López , A. L. ., Rivero Espejel , . I. A. ., & Cornejo Bravo , J. M. . (2022). Toxicity evaluation of thermosensitive nanogels in an in vivo model. REVISTA DE CIENCIAS TECNOLÓGICAS (RECIT), 5(3), e236. https://doi.org/10.37636/recit.v5n3e236

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