Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity
Keywords:Silver Nanoparticles, Nanotoxicology, Biological Systems Complexity, Antimicrobial Activity.
AbstractCurrently, silver nanoparticles (AgNPs) are extensively studied for biomedical applications, but although nanomaterials provide many benefits, recently their comparative toxicity have barely been explored. In the current work, AgNPs toxicity on biological systems of different levels of complexity was assessed in a comprehensive and comparatively way. The organisms included viruses, bacteria, microalgae, fungi, animal and human cells (including cancer cell lines). We found that growth of biological systems of different taxonomical groups –in vitro, at a cellular level- is inhibited at concentrations of AgNPs within the same order of magnitude (101 μg/ml). Thus, the AgNPs toxicity does not depend on the complexity of the organisms. The fact that cells and virus are inhibited with a concentration of AgNPs within the same order of magnitude could be explained considering that silver affects fundamental structures for cells and virus alike.
H. H. Lara, E. N. Garza-Treviño, L. Ixtepan- Turrent, and D. K. Singh, "Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds.," J. Nanobiotechnology, vol. 9, p. 30, 2011. https://doi.org/10.1186/1477-3155-9-30 DOI: https://doi.org/10.1186/1477-3155-9-30
G. Franci, A. Falanga, S. Galdiero, L. Palomba, and M. Rai, "Silver nanoparticles as potential antibacterial agents," Molecules, 2015. https://doi.org/10.3390/molecules20058856 DOI: https://doi.org/10.3390/molecules20058856
J. Il Kwak and Y.-J. An, "Trophic transfer of silver nanoparticles from earthworms disrupts the locomotion of springtails (Collembola)," J. Hazard. Mater., May 2016. https://doi.org/10.1016/j.jhazmat.2016.05.005 DOI: https://doi.org/10.1016/j.jhazmat.2016.05.005
F. Martinez-Gutierrez, P. L. Olive, A. Banuelos, E. Orrantia, N. Nino, E. M. Sanchez, F. Ruiz, H. Bach, and Y. Av-Gay, "Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles," Nanomedicine Nanotechnology, Biol. Med., vol. 6, no. 5, pp. 681-688, 2010. https://doi.org/10.1016/j.nano.2010.02.001 DOI: https://doi.org/10.1016/j.nano.2010.02.001
A. Panáček, M. Kolář, R. Večeřová, R. Prucek, J. Soukupová, V. Kryštof, P. Hamal, R. Zbořil, and L. Kvítek, "Antifungal activity of silver nanoparticles against Candida spp.," Biomaterials, vol. 30, no. 31, pp. 6333-6340, 2009. https://doi.org/10.1016/j.biomaterials.2009.07.065 DOI: https://doi.org/10.1016/j.biomaterials.2009.07.065
F. Seitz, R. R. Rosenfeldt, K. Storm, G. Metreveli, G. E. Schaumann, R. Schulz, and M. Bundschuh, "Effects of silver nanoparticle properties, media pH and dissolved organic matter on toxicity to Daphnia magna," Ecotoxicol. Environ. Saf., vol. 111, pp. 263-270, 2015. https://doi.org/10.1016/j.ecoenv.2014.09.031 DOI: https://doi.org/10.1016/j.ecoenv.2014.09.031
C. Greulich, D. Braun, A. Peetsch, J. Diendorf, B. Siebers, M. Epple, and M. Köller, "The toxic effect of silver ions and silver nanoparticles towards bacteria and human cells occurs in the same concentration range," RSC Advances, vol. 2, no. 17. p. 6981, 2012. https://doi.org/10.1039/c2ra20684f DOI: https://doi.org/10.1039/c2ra20684f
J. You, Y. Zhang, and Z. Hu, "Bacteria and bacteriophage inactivation by silver and zinc oxide nanoparticles," Colloids Surfaces B Biointerfaces, vol. 85, no. 2, pp. 161-167, 2011. https://doi.org/10.1016/j.colsurfb.2011.02.023 DOI: https://doi.org/10.1016/j.colsurfb.2011.02.023
S. Ghosh, R. Kaushik, K. Nagalakshmi, S. L. Hoti, G. a. Menezes, B. N. Harish, and H. N. Vasan, "Antimicrobial activity of highly stable silver nanoparticles embedded in agar- agar matrix as a thin film," Carbohydr. Res., vol. 345, no. 15, pp. 2220-2227, 2010. https://doi.org/10.1016/j.carres.2010.08.001 DOI: https://doi.org/10.1016/j.carres.2010.08.001
T. Mosmann, "Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.," J. Immunol. Methods, vol. 65, no. 1-2, pp. 55- 63, Dec. 1983. https://doi.org/10.1016/0022-1759(83)90303-4 DOI: https://doi.org/10.1016/0022-1759(83)90303-4
Vazquez-Muñoz, R., Borrego, B., Juárez- Moreno, K., García-García, M., Mota Morales, J. D., Bogdanchikova, N., & Huerta-Saquero, A. (2017). Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter? Toxicology Letters, 276, 11-20. https://doi.org/10.1016/j.toxlet.2017.05.007 DOI: https://doi.org/10.1016/j.toxlet.2017.05.007
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Copyright (c) 2018 Vázquez-Muñoz Roberto, Borrego-Rivero Belén, Juárez-Moreno Karla Oyuky, García-García Maritza Roxana, Mota Morales Josué David, Bogdanchinkova Nina, Huerta-Saquero Alejandro
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