Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity
DOI:
https://doi.org/10.37636/recit.v11811Keywords:
Silver Nanoparticles, Nanotoxicology, Biological Systems Complexity, Antimicrobial Activity.Abstract
Currently, silver nanoparticles (AgNPs) are extensively studied for biomedical applications, but although nanomaterials provide many benefits, recently their comparative toxicity have barely been explored. In the current work, AgNPs toxicity on biological systems of different levels of complexity was assessed in a comprehensive and comparatively way. The organisms included viruses, bacteria, microalgae, fungi, animal and human cells (including cancer cell lines). We found that growth of biological systems of different taxonomical groups –in vitro, at a cellular level- is inhibited at concentrations of AgNPs within the same order of magnitude (101 μg/ml). Thus, the AgNPs toxicity does not depend on the complexity of the organisms. The fact that cells and virus are inhibited with a concentration of AgNPs within the same order of magnitude could be explained considering that silver affects fundamental structures for cells and virus alike.Downloads
References
H. H. Lara, E. N. Garza-Treviño, L. Ixtepan- Turrent, and D. K. Singh, "Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds.," J. Nanobiotechnology, vol. 9, p. 30, 2011. https://doi.org/10.1186/1477-3155-9-30 DOI: https://doi.org/10.1186/1477-3155-9-30
G. Franci, A. Falanga, S. Galdiero, L. Palomba, and M. Rai, "Silver nanoparticles as potential antibacterial agents," Molecules, 2015. https://doi.org/10.3390/molecules20058856 DOI: https://doi.org/10.3390/molecules20058856
J. Il Kwak and Y.-J. An, "Trophic transfer of silver nanoparticles from earthworms disrupts the locomotion of springtails (Collembola)," J. Hazard. Mater., May 2016. https://doi.org/10.1016/j.jhazmat.2016.05.005 DOI: https://doi.org/10.1016/j.jhazmat.2016.05.005
F. Martinez-Gutierrez, P. L. Olive, A. Banuelos, E. Orrantia, N. Nino, E. M. Sanchez, F. Ruiz, H. Bach, and Y. Av-Gay, "Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles," Nanomedicine Nanotechnology, Biol. Med., vol. 6, no. 5, pp. 681-688, 2010. https://doi.org/10.1016/j.nano.2010.02.001 DOI: https://doi.org/10.1016/j.nano.2010.02.001
A. Panáček, M. Kolář, R. Večeřová, R. Prucek, J. Soukupová, V. Kryštof, P. Hamal, R. Zbořil, and L. Kvítek, "Antifungal activity of silver nanoparticles against Candida spp.," Biomaterials, vol. 30, no. 31, pp. 6333-6340, 2009. https://doi.org/10.1016/j.biomaterials.2009.07.065 DOI: https://doi.org/10.1016/j.biomaterials.2009.07.065
F. Seitz, R. R. Rosenfeldt, K. Storm, G. Metreveli, G. E. Schaumann, R. Schulz, and M. Bundschuh, "Effects of silver nanoparticle properties, media pH and dissolved organic matter on toxicity to Daphnia magna," Ecotoxicol. Environ. Saf., vol. 111, pp. 263-270, 2015. https://doi.org/10.1016/j.ecoenv.2014.09.031 DOI: https://doi.org/10.1016/j.ecoenv.2014.09.031
C. Greulich, D. Braun, A. Peetsch, J. Diendorf, B. Siebers, M. Epple, and M. Köller, "The toxic effect of silver ions and silver nanoparticles towards bacteria and human cells occurs in the same concentration range," RSC Advances, vol. 2, no. 17. p. 6981, 2012. https://doi.org/10.1039/c2ra20684f DOI: https://doi.org/10.1039/c2ra20684f
J. You, Y. Zhang, and Z. Hu, "Bacteria and bacteriophage inactivation by silver and zinc oxide nanoparticles," Colloids Surfaces B Biointerfaces, vol. 85, no. 2, pp. 161-167, 2011. https://doi.org/10.1016/j.colsurfb.2011.02.023 DOI: https://doi.org/10.1016/j.colsurfb.2011.02.023
S. Ghosh, R. Kaushik, K. Nagalakshmi, S. L. Hoti, G. a. Menezes, B. N. Harish, and H. N. Vasan, "Antimicrobial activity of highly stable silver nanoparticles embedded in agar- agar matrix as a thin film," Carbohydr. Res., vol. 345, no. 15, pp. 2220-2227, 2010. https://doi.org/10.1016/j.carres.2010.08.001 DOI: https://doi.org/10.1016/j.carres.2010.08.001
T. Mosmann, "Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.," J. Immunol. Methods, vol. 65, no. 1-2, pp. 55- 63, Dec. 1983. https://doi.org/10.1016/0022-1759(83)90303-4 DOI: https://doi.org/10.1016/0022-1759(83)90303-4
Vazquez-Muñoz, R., Borrego, B., Juárez- Moreno, K., García-García, M., Mota Morales, J. D., Bogdanchikova, N., & Huerta-Saquero, A. (2017). Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter? Toxicology Letters, 276, 11-20. https://doi.org/10.1016/j.toxlet.2017.05.007 DOI: https://doi.org/10.1016/j.toxlet.2017.05.007
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2018 Vázquez-Muñoz Roberto, Borrego-Rivero Belén, Juárez-Moreno Karla Oyuky, García-García Maritza Roxana, Mota Morales Josué David, Bogdanchinkova Nina, Huerta-Saquero Alejandro
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors who publish in this journal accept the following conditions:
The authors retain the copyright and assign to the journal the right of the first publication, with the work registered with the Creative Commons Attribution license 4.0, which allows third parties to use what is published as long as they mention the authorship of the work and the first publication in this magazine.
Authors may make other independent and additional contractual agreements for the non-exclusive distribution of the version of the article published in this journal (eg, include it in an institutional repository or publish it in a book) as long as they clearly indicate that the work it was first published in this magazine.
Authors are allowed and encouraged to share their work online (for example: in institutional repositories or personal web pages) before and during the manuscript submission process, as it can lead to productive exchanges, greater and more quick citation of published work (see The Effect of Open Access).
