Diabetic foot ulcers treatment with silver nanoparticles

Authors

  • Cesar Alejandro Almonaci Hernández Integral and Advance Clinic, Ensenada, Baja California, México.
  • Isis Marion Cabrera Torres Integral and Advance Clinic, Ensenada, Baja California, México. https://orcid.org/0000-0002-7980-3361
  • Rosangela López-Acevedo Integral and Advance Clinic, Ensenada, Baja California, México.
  • Karla Oyuki Juárez-Moreno Center of Nanoscience and Nanotechnology, National Autonomous University of Mexico. Km107 Carretera Tijuana-Ensenada, Ensenada, Baja California, México. CONACYT Research Fellow at Center of Nanoscience and Nanotechnology, National Autonomous University of Mexico. Ensenada, Baja California, México. https://orcid.org/0000-0002-6171-8601
  • Martin E. Castañeda-Juárez CONACYT Research Fellow at Center of Nanoscience and Nanotechnology, National Autonomous University of Mexico. Ensenada, Baja California, México.
  • Horacio Almanza-Reyes School of Medicine. National Autonomous University of Mexico, Ensenada, Baja California, México https://orcid.org/0000-0002-1874-3975
  • Alexey Pestryakov Tomsk Polytechnic University, Tomsk, Russia. https://orcid.org/0000-0002-9034-4733
  • Nina Bogdanchikova Center of Nanoscience and Nanotechnology, National Autonomous University of Mexico. Km107 Carretera Tijuana-Ensenada, Ensenada, Baja California, México. https://orcid.org/0000-0003-0929-3535

DOI:

https://doi.org/10.37636/recit.v212025

Keywords:

Diabetic Foot Ulcers, Diabetes Mellitus, Silver Nanoparticles, Nanomedicine, Chronic Ulcers.

Abstract

Diabetic foot ulcers are highly susceptible to microbial infections and are the leading cause of lower limb hospitalization and amputation in diabetic patients. Due to their antimicrobial and anti-inflammatory properties, silver nanoparticles (AgNPs) are the most widely used nanomaterial in biomedicine. Herein, we present the usage of AgNPs for the treatment of diabetic foot ulcers with a stage II in Wagner classification. In addition to conventional antibiotic treatment, the ulcers were treated with topical administration of AgNPs at a concentration of 1.2 mg/ml of metallic silver. The results showed a significant improvement in the evolution of the ulcers, where the edges of the lesion were effectively approached, granulation tissue being observed, edema decreased and fibrin plaques. These results form the basis for further studies on the use of AgNPs for the treatment of chronic ulcers of different origins.

Downloads

Download data is not yet available.

References

J. P. Hernández-Ávila,Mauricio Gutiérrez and N. Reynoso-Noverón, "Diabetes mellitus en México. El estado de la epidemia," Salud Pública de México, vol. 55, no. 2, p. 129-S136., 2013. https://doi.org/10.21149/spm.v55s2.5108

S. Lopez-Antuñano and F. J. López- Antuñano, "Disponible en: http://www.redalyc.org/articulo.oa?id=1064 0310," Salud Publica Mex., vol. 40, no. 4, pp. 281-292, 1998. https://doi.org/10.1590/S0036-36341998000300010

M. S. Bader, "Diabetic foot infection.," Am. Fam. Physician, vol. 78, no. 1, pp. 71-9, 2008. https://www.aafp.org/afp/2008/0701/p71.html

E. J. Boyko, J. H. Ahroni, V. Cohen, K. M. Nelson, and P. J. Heagerty, "Prediction of diabetic foot ulcer occurrence using commonly available clinical information: the Seattle Diabetic Foot Study.," Diabetes Care, vol. 29, no. 6, pp. 1202-7, Jun. 2006. https://doi.org/10.2337/dc05-2031

J. Apelqvist and J. Larsson, "What is the most effective way to reduce incidence of amputation in the diabetic foot?," Diabetes. Metab. Res. Rev., vol. 16 Suppl 1, pp. S75- 83, Jan. https://doi.org/10.1002/1520-7560(200009/10)16:1+<::AID-DMRR139>3.0.CO;2-8

I. UcKay, K. Gariani, Z. Pataky, and B. A. Lipsky, "Diabetic foot infections: State-of- the-art," Diabetes, Obes. Metab., vol. 16, no. 4, pp. 305-316, 2014. https://doi.org/10.1111/dom.12190

W. J. Jeffcoate and K. G. Harding, "Diabetic foot ulcers," Lancet, vol. 361, no. 9368, pp. 1545-1551, May 2003. https://doi.org/10.1016/S0140-6736(03)13169-8

T. J. Boffeli, "Partial Foot Amputations for Salvage of the Diabetic Lower Extremity," Clin. Pod. Med. Surg., vol. 31, pp. 103-126, 2014. https://doi.org/10.1016/j.cpm.2013.09.005

D. D. A. Martinez-Gomez, C. Ramirez- Almagro, A. Campillo-Soto, G. Morales- Cuenca, J. Pagan-Ortiz, and J. L. Aguayo- Albasini, "Infecciones del pie diabético. Prevalencia de los distintos microorganismos y sensibilidad a los antimicrobianos," Enferm. Infecc. Microbiol. Clin., vol. 27, no. 6, pp. 317-321, 2009. https://doi.org/10.1016/j.eimc.2008.07.004

B. S. Atiyeh, M. Costagliola, S. N. Hayek, and S. A. Dibo, "Effect of silver on burn wound infection control and healing: Review of the literature," Burns, vol. 33, no. 2, pp. 139-148, 2007. https://doi.org/10.1016/j.burns.2006.06.010

S. Krol, R. Ellis-Behnke, and P. Marchetti, "Nanomedicine for treatment of diabetes in an aging population: State-of-the-art and future developments," Maturitas, vol. 73, no. 1, pp. 61-67, 2012. https://doi.org/10.1016/j.maturitas.2011.12.004

H. H. Lara, N. V. Ayala-Núñez, L. del C. Ixtepan Turrent, and C. Rodríguez Padilla, "Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria," World J. Microbiol. Biotechnol., vol. 26, no. 4, pp. 615-621, Oct. 2009. https://doi.org/10.1007/s11274-009-0211-3

T. Gunasekaran, T. Nigusse, and M. D. Dhanaraju, "Silver nanoparticles as real topical bullets for wound healing," Journal of the American College of Clinical Wound Specialists, vol. 3, no. 4. pp. 82-96, Dec- 2011. https://doi.org/10.1016/j.jcws.2012.05.001

B. S. Anisha, R. Biswas, K. P. Chennazhi, and R. Jayakumar, "Chitosan-hyaluronic acid/nano silver composite sponges for drug resistant bacteria infected diabetic wounds," Int. J. Biol. Macromol., vol. 62, pp. 310-320, Nov. 2013. https://doi.org/10.1016/j.ijbiomac.2013.09.011

J. Tian, K. K. Y. Wong, C. M. Ho, C. N. Lok, W. Y. Yu, C. M. Che, J. F. Chiu, and P. K. H. Tam, "Topical delivery of silver nanoparticles promotes wound healing," ChemMedChem, vol. 2, no. 1, pp. 129-136, Jan. 2007. https://doi.org/10.1002/cmdc.200600171

C. A Almonaci H., K. Juárez-Moreno, M. E. Castañeda-Juárez, H. Almanza-Reyes, A. Pestryakov and N. Bogdanchikova "Silver nanoparticles for the rapid healing of diabetic foot ulcers.", International Journal of Medical Nano Research, vol. 4, no 1, pp. 1-6, 2017. https://doi.org/10.23937/2378-3664/1410019

B. Borrego, G. Lorenzo, J. D. Mota-Morales, H. Almanza-Reyes, F. Mateos, E. López-Gil, N. de la Losa, V. A. Burmistrov, A. N. Pestryakov, A. Brun, and N. Bogdanchikova, "Potential application of silver nanoparticles to control the infectivity of rift valley fever virus in vitro and in vivo.," Nanomedicine, vol. 12, no. 5, pp. 1185-1192, Mar. 2016. https://doi.org/10.1016/j.nano.2016.01.021

K. Juarez-Moreno, E. B. Gonzalez, N. Girón-Vazquez, A. Chávez, J. D. M. Morales, L. L. Perez-Mozqueda, M. R. Garcia-Garcia, A. Pestryakov, and N. Bogdanchikova, "Comparison of cytotoxicity and genotoxicity effects of silver nanoparticles on human cervix and breast cancer cell lines," Hum. Exp. Toxicol., vol. 36, no. 9, pp. 931-948, 2016. https://doi.org/10.1177/0960327116675206

Chronological evolution of the lesion of diabetic foot ulcers classified as Wagner grade II, treated with topical administration of AgNPs. DFU from (A) 46 years-old male patient with type-2 diabetes and (B) 40 years-old male patient with type-2 diabetes. In both figures (A and B) initial appearance of the ulcer is shown and the evolution of the DFU after several days of treatment with AgNPs solution.

Additional Files

Published

2019-01-20

How to Cite

Almonaci Hernández, C. A., Cabrera Torres, I. M., López-Acevedo, R., Juárez-Moreno, K. O., Castañeda-Juárez, M. E., Almanza-Reyes, H., Pestryakov, A., & Bogdanchikova, N. (2019). Diabetic foot ulcers treatment with silver nanoparticles. REVISTA DE CIENCIAS TECNOLÓGICAS (RECIT), 2(1), 20–25. https://doi.org/10.37636/recit.v212025

Issue

Section

Research articles

Categories

Most read articles by the same author(s)