Diabetic foot ulcers treatment with silver nanoparticles


  • Cesar Alejandro Almonaci Hernández Integral and Advance Clinic, Ensenada, Baja California, México.
  • Isis Marion Cabrera Torres Integral and Advance Clinic, Ensenada, Baja California, México. https://orcid.org/0000-0002-7980-3361
  • Rosangela López-Acevedo Integral and Advance Clinic, Ensenada, Baja California, México.
  • Karla Oyuki Juárez-Moreno Center of Nanoscience and Nanotechnology, National Autonomous University of Mexico. Km107 Carretera Tijuana-Ensenada, Ensenada, Baja California, México. CONACYT Research Fellow at Center of Nanoscience and Nanotechnology, National Autonomous University of Mexico. Ensenada, Baja California, México. https://orcid.org/0000-0002-6171-8601
  • Martin E. Castañeda-Juárez CONACYT Research Fellow at Center of Nanoscience and Nanotechnology, National Autonomous University of Mexico. Ensenada, Baja California, México.
  • Horacio Almanza-Reyes School of Medicine. National Autonomous University of Mexico, Ensenada, Baja California, México https://orcid.org/0000-0002-1874-3975
  • Alexey Pestryakov Tomsk Polytechnic University, Tomsk, Russia. https://orcid.org/0000-0002-9034-4733
  • Nina Bogdanchikova Center of Nanoscience and Nanotechnology, National Autonomous University of Mexico. Km107 Carretera Tijuana-Ensenada, Ensenada, Baja California, México. https://orcid.org/0000-0003-0929-3535




Diabetic Foot Ulcers, Diabetes Mellitus, Silver Nanoparticles, Nanomedicine, Chronic Ulcers.


Diabetic foot ulcers are highly susceptible to microbial infections and are the leading cause of lower limb hospitalization and amputation in diabetic patients. Due to their antimicrobial and anti-inflammatory properties, silver nanoparticles (AgNPs) are the most widely used nanomaterial in biomedicine. Herein, we present the usage of AgNPs for the treatment of diabetic foot ulcers with a stage II in Wagner classification. In addition to conventional antibiotic treatment, the ulcers were treated with topical administration of AgNPs at a concentration of 1.2 mg/ml of metallic silver. The results showed a significant improvement in the evolution of the ulcers, where the edges of the lesion were effectively approached, granulation tissue being observed, edema decreased and fibrin plaques. These results form the basis for further studies on the use of AgNPs for the treatment of chronic ulcers of different origins.


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Chronological evolution of the lesion of diabetic foot ulcers classified as Wagner grade II, treated with topical administration of AgNPs. DFU from (A) 46 years-old male patient with type-2 diabetes and (B) 40 years-old male patient with type-2 diabetes. In both figures (A and B) initial appearance of the ulcer is shown and the evolution of the DFU after several days of treatment with AgNPs solution.

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How to Cite

Almonaci Hernández, C. A., Cabrera Torres, I. M., López-Acevedo, R., Juárez-Moreno, K. O., Castañeda-Juárez, M. E., Almanza-Reyes, H., Pestryakov, A., & Bogdanchikova, N. (2019). Diabetic foot ulcers treatment with silver nanoparticles. REVISTA DE CIENCIAS TECNOLÓGICAS (RECIT), 2(1), 20–25. https://doi.org/10.37636/recit.v212025



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