Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity

Authors

  • Roberto Vázquez-Muñoz Nanoscience and Nanotechnology Center, National Autonomous University of Mexico, Km 107, Tijuana-Ensenada Highway. CP 22860, Ensenada, Baja California, Mexico. https://orcid.org/0000-0002-3847-1305
  • Belén Borrego-Rivero Animal Health Research Center, INIA (National Research Institute for Agricultural and Food; Technology), Carretera Algete el Casar s / n. 28130. Valdeolmos, Madrid, Spain. https://orcid.org/0000-0002-0801-9166
  • Karla Oyuky Juárez-Moreno Nanoscience and Nanotechnology Center, National Autonomous University of Mexico, Km 107, Tijuana-Ensenada Highway. CP 22860, Ensenada, Baja California, Mexico. https://orcid.org/0000-0002-6171-8601
  • Maritza Roxana García-García Nanoscience and Nanotechnology Center, National Autonomous University of Mexico, Km 107, Tijuana-Ensenada Highway. CP 22860, Ensenada, Baja California, Mexico. https://orcid.org/0000-0002-2996-8264
  • Josué David Mota-Morales Nanoscience and Nanotechnology Center, National Autonomous University of Mexico, Km 107, Tijuana-Ensenada Highway. CP 22860, Ensenada, Baja California, Mexico. Center for Applied Physics and Advanced Technology. National Autonomous University of Mexico, Querétaro, Querétaro 76230, Mexico. https://orcid.org/0000-0001-8257-0709
  • Nina Bogdanchikova Nanoscience and Nanotechnology Center, National Autonomous University of Mexico, Km 107, Tijuana-Ensenada Highway. CP 22860, Ensenada, Baja California, Mexico. https://orcid.org/0000-0003-0929-3535
  • Alejandro Huerta-Saquero Nanoscience and Nanotechnology Center, National Autonomous University of Mexico, Km 107, Tijuana-Ensenada Highway. CP 22860, Ensenada, Baja California, Mexico. https://orcid.org/0000-0002-0156-6773

DOI:

https://doi.org/10.37636/recit.v11811

Keywords:

Silver Nanoparticles, Nanotoxicology, Biological Systems Complexity, Antimicrobial Activity.

Abstract

Currently, silver nanoparticles (AgNPs) are extensively studied for biomedical applications, but although nanomaterials provide many benefits, recently their comparative toxicity have barely been explored. In the current work, AgNPs toxicity on biological systems of different levels of complexity was assessed in a comprehensive and comparatively way. The organisms included viruses, bacteria, microalgae, fungi, animal and human cells (including cancer cell lines). We found that growth of biological systems of different taxonomical groups –in vitro, at a cellular level- is inhibited at concentrations of AgNPs within the same order of magnitude (101 μg/ml). Thus, the AgNPs toxicity does not depend on the complexity of the organisms. The fact that cells and virus are inhibited with a concentration of AgNPs within the same order of magnitude could be explained considering that silver affects fundamental structures for cells and virus alike.

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References

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Vazquez-Muñoz, R., Borrego, B., Juárez- Moreno, K., García-García, M., Mota Morales, J. D., Bogdanchikova, N., & Huerta-Saquero, A. (2017). Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter? Toxicology Letters, 276, 11-20. https://doi.org/10.1016/j.toxlet.2017.05.007

AgNPs characterization. TEM micrography and UV-Vis profile

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Published

2018-09-01

How to Cite

Vázquez-Muñoz, R., Borrego-Rivero, B., Juárez-Moreno, K. O., García-García, M. R., Mota-Morales, J. D., Bogdanchikova, N., & Huerta-Saquero, A. (2018). Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity. REVISTA DE CIENCIAS TECNOLÓGICAS (RECIT), 1(1), 8–11. https://doi.org/10.37636/recit.v11811

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