Effect on antimicrobial activity of antifungal agents-silver nanoparticles combined treatments

Authors

  • Yarithza Pérez Arriola Autonomous University of Baja California (UABC); Carretera Tijuana-Ensenada 3917, Playitas, 22860. Ensenada, Baja California, Mexico
  • Roberto Vázquez Muñoz Center for Nanosciences and Nanotechnology (CNyN); National Autonomous University of Mexico, Apartado Postal 14, CP 22800; Ensenada, Baja California, Mexico Ensenada Center for Scientific Research and Higher Education, Carretera Tijuana-Ensenada 3918; CP 22860, Ensenada, Baja California, Mexico https://orcid.org/0000-0002-3847-1305
  • Nina Bogdanchikova Center for Nanosciences and Nanotechnology (CNyN); National Autonomous University of Mexico, Apartado Postal 14, CP 22800; Ensenada, Baja California, Mexico https://orcid.org/0000-0003-0929-3535
  • Alejandro Huerta Saquero Center for Nanosciences and Nanotechnology (CNyN); National Autonomous University of Mexico, Apartado Postal 14, CP 22800; Ensenada, Baja California, Mexico https://orcid.org/0000-0002-0156-6773

DOI:

https://doi.org/10.37636/recit.v126971

Keywords:

Nanoantibiotics, Silver Nanoparticles, Infectious Diseases, Synergy, Candida albicans.

Abstract

Infectious diseases are a global public health problem; they are among the leading causes of death worldwide and consume a significant amount of resources. Fungi are the most common pathogens in humans and animals. Fungal infections incidence has increased more than 200%. Currently, antifungal agents are used for combating fungal infections, but there are many problems associated with their use, such as the emergence of resistant organisms, as well as the complexity related to the development of new antibiotics. In that sense, silver nanoparticles have proven to be an alternative solution to fight fungal infections due their capacity to inhibit fungal growth. In this work, we studied the antimicrobial activity of silver nanoparticles (AgNPs), antifungal agents (Amphotericin B and Fluconazole) and combinations of both, AgNPs-antifungals over the pathogenic dimorphic yeast Candida albicans. The antimicrobial tests were performed according to the CLSI ́s M27-A3 protocols. Combined AgNPs-antifungal treatments showed a different effect on antimicrobial activity. We found a synergistic effect of specific combined treatment, whereas antagonistic effect was observed with other combination.

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References

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The effect on the dimorphic capacity of C. albicans, treated with sub-lethal concentration of the antimicrobial agents. A) Control; B) Cells with AgNPs; C) Cells with ApB; D) Cells with ApB-AgNPs; E) Cells with Flu; and F) Cells with Flu-AgNPs

Published

2018-01-01

How to Cite

Pérez Arriola, Y., Vázquez Muñoz, R., Bogdanchikova, N., & Huerta Saquero, A. (2018). Effect on antimicrobial activity of antifungal agents-silver nanoparticles combined treatments. REVISTA DE CIENCIAS TECNOLÓGICAS (RECIT), 1(2), 69–71. https://doi.org/10.37636/recit.v126971

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